Description
Star formation is modified in molecular clouds by feedback from young massive stars. Pre-supernova feedback mechanisms are particularly important as they will set the stage for supernovae and the dispersal of energy out into the wider galactic environment, thus altering galaxy evolution. I describe how star formation and feedback can depend on galactic environment, for example for different gas surface densities and metallicities, and for spiral arms vs. inter-arm regions vs. galactic centres. I highlight how simulations are able to connect different physical scales using zoom-in simulations, going from galaxies to the interstellar medium. I also discuss how the relative impacts of different feedback mechanisms can be quantified from observations of real star forming regions, and how they can be interpreted using simulations and synthetic observations.